Abstract
A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect associated with L-dopa (LD) therapy. Target compounds release LD and dopamine (DA) in human plasma after enzymatic hydrolysis, displaying an antioxidant effect superior to that of N-acetylcysteine (NAC). After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD.
MeSH terms
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Analysis of Variance
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Animals
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Antioxidants / chemistry
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Antioxidants / pharmacokinetics
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Antioxidants / therapeutic use*
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Antiparkinson Agents / chemistry
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Antiparkinson Agents / pharmacokinetics
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Antiparkinson Agents / therapeutic use*
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Area Under Curve
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Chromatography, High Pressure Liquid
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Corpus Striatum / metabolism
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Half-Life
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Humans
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Injections, Intraventricular
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Levodopa / analysis*
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Parkinson Disease / drug therapy*
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Rats
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Spectrophotometry, Ultraviolet
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Sulfur / analysis*
Substances
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Antioxidants
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Antiparkinson Agents
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Levodopa
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Sulfur