Targeted delivery of activatable fluorescent pro-apoptotic peptide into live cells

Org Biomol Chem. 2009 Jan 21;7(2):221-4. doi: 10.1039/b817251j. Epub 2008 Nov 17.

Abstract

A new fluorescence imaging system is used to visualize the specific cytotoxic biomolecule delivery within living biological samples by means of FRET quenching.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Carbocyanines / administration & dosage
  • Carbocyanines / chemistry
  • Cells, Cultured
  • Drug Carriers / chemistry*
  • Fluorescence Resonance Energy Transfer / methods
  • Fluorescent Dyes / administration & dosage
  • Fluorescent Dyes / chemistry*
  • Humans
  • Indoles / chemistry*
  • Intercellular Signaling Peptides and Proteins
  • Peptides / administration & dosage*
  • Peptides / chemistry
  • Peptides, Cyclic / chemistry*

Substances

  • Carbocyanines
  • Drug Carriers
  • Fluorescent Dyes
  • Indoles
  • Intercellular Signaling Peptides and Proteins
  • KLA peptide
  • Peptides
  • Peptides, Cyclic
  • cyanine dye 5