Abstract
By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antifungal Agents / administration & dosage
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Antifungal Agents / blood
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Antifungal Agents / pharmacokinetics*
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Area Under Curve
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Blood Urea Nitrogen
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Bronchi / metabolism*
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Bronchoalveolar Lavage Fluid / chemistry
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Bronchoalveolar Lavage Fluid / cytology
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Bronchoscopy
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Clinical Trials, Phase I as Topic
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Echinocandins / administration & dosage
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Echinocandins / blood
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Echinocandins / pharmacokinetics*
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Epithelium / metabolism
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Humans
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Lipopeptides / administration & dosage
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Lipopeptides / blood
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Lipopeptides / pharmacokinetics*
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Lung / metabolism*
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Macrophages, Alveolar / metabolism
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Micafungin
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Middle Aged
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Prospective Studies
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Pulmonary Alveoli / metabolism
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Micafungin