Abstract
Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology*
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Animals
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Anti-Obesity Agents / chemical synthesis*
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Anti-Obesity Agents / pharmacology*
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CHO Cells
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Cricetinae
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Cricetulus
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Humans
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Indicators and Reagents
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Receptors, Somatostatin / antagonists & inhibitors*
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Solvents
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Structure-Activity Relationship
Substances
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Amides
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Anti-Obesity Agents
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Indicators and Reagents
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MCHR1 protein, human
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Receptors, Somatostatin
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Solvents