Abstract
One new diterpene glycoside (1) named 16-O-alpha-D-tetraacetylglucopyranosyl hymatoxin C, along with eight known ones including two diterpenoids (2, 3), three cytochalasins (4, 5, 6), dihydroisocoumarin (7) and two C(7)-tetraketides (8, 9), were isolated from the culture of the endophytic fungal strain Tubercularia sp. TF5. The structures of compounds 1-9 were elucidated by spectroscopic methods. The cytotoxic and antimicrobial activities of 1 were analysed but showed no significant activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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China
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Cytochalasins / chemistry
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Cytochalasins / isolation & purification*
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Cytochalasins / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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HeLa Cells
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Humans
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Hypocreales / chemistry*
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Taxus / microbiology*
Substances
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16-O-alpha-D-tetraacetylglucopyranosyl hymatoxin C
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Coumarins
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Cytochalasins
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Diterpenes
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Glucosides
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Macrolides