Abstract
Thirty-two patients with locally advanced cancer of oral cavity, oropharynx and hypopharynx were treated with three cycles of platinum-based induction chemotherapy followed by radiation therapy. After completion of the combined treatment 50% of the patients were in complete response (CR) and 28% in partial response (PR). So far, 24 patients have died. Local progression occurred in 20 patients. Survival is 29% at 24 months. Seven (22%) patients remain alive and have been disease-free for 22-59 months. In conclusion, induction chemotherapy followed by radiation therapy may omit radical surgery, without compromising survival, in some patients with locally advanced cancer of the oral cavity, oropharynx and hypopharynx.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carboplatin / administration & dosage
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / radiotherapy
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Carcinoma, Squamous Cell / therapy*
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Female
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Humans
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Hydroxyurea / administration & dosage
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Hypopharyngeal Neoplasms / drug therapy
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Hypopharyngeal Neoplasms / radiotherapy
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Hypopharyngeal Neoplasms / therapy*
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Male
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Middle Aged
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Mitomycins / administration & dosage
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Mouth Neoplasms / drug therapy
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Mouth Neoplasms / radiotherapy
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Mouth Neoplasms / therapy*
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Oropharyngeal Neoplasms / drug therapy
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Oropharyngeal Neoplasms / radiotherapy
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Oropharyngeal Neoplasms / therapy*
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Remission Induction
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Retrospective Studies
Substances
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Mitomycins
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Carboplatin
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Cisplatin
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Hydroxyurea