Synchronisation in the beta frequency-band--the bad boy of parkinsonism or an innocent bystander?

Exp Neurol. 2009 May;217(1):1-3. doi: 10.1016/j.expneurol.2009.02.003. Epub 2009 Feb 20.

Abstract

Excessive synchronisation of basal ganglia neuronal activity in the beta frequency band has been implicated in Parkinson's disease. In a recent issue of Experimental Neurology, Bronte-Stewart, H., Barberini, C., Koop, M.M., Hill, B.C., Henderson, J.M., Wingeier, B., 2009. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 215, 20-28. demonstrate that such activity is consistent over time and provide further evidence that deep brain stimulation is associated with its suppression. However, the extent to which beta synchrony has a mechanistic (rather than epiphenomenal) role in parkinsonism remains unclear, and the suppression of this activity by deep brain stimulation is contentious. This commentary discusses the evidence for and against a role for excessive beta synchrony in mediating the parkinsonian phenotype and in providing a possible mechanism to explain the therapeutic effects of deep brain stimulation in Parkinson's disease.

Publication types

  • Kommentar
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Beta Rhythm*
  • Deep Brain Stimulation / methods
  • Humans
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / therapy