Abstract
The expression of granulysin, a cytolytic protein produced by activated T and NK cells, has been revealed to be correlated with the prognosis of some adult cancer patients. By examination on various childhood lymphoma tissues, we found that granulysin level was especially high in systemic anaplastic large cell lymphoma (ALCL) cases, whereas no close correlation with the expression of CD96, a marker for activated T and NK cells, was observed. We further demonstrated that both ALCL cells in biopsy specimens and cell lines established from ALCL express granulysin, indicating some correlation of granulysin with biological features of ALCL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, CD / genetics
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Antigens, CD / metabolism
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Antigens, Differentiation, T-Lymphocyte / genetics*
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Antigens, Differentiation, T-Lymphocyte / metabolism
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Burkitt Lymphoma / genetics*
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Burkitt Lymphoma / metabolism
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Burkitt Lymphoma / pathology
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Female
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Flow Cytometry
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Hodgkin Disease / genetics*
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Hodgkin Disease / metabolism
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Hodgkin Disease / pathology
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Humans
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Killer Cells, Natural / metabolism
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Killer Cells, Natural / pathology
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Lymphoma, B-Cell / genetics*
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Lymphoma, B-Cell / metabolism
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Lymphoma, B-Cell / pathology
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Lymphoma, Large B-Cell, Diffuse / metabolism
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large-Cell, Anaplastic / genetics*
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Lymphoma, Large-Cell, Anaplastic / metabolism
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Lymphoma, Large-Cell, Anaplastic / pathology
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Male
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Middle Aged
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Prognosis
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Tumor Cells, Cultured
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Young Adult
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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Biomarkers, Tumor
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CD96 antigen
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GNLY protein, human
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RNA, Messenger