Abstract
The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Bone and Bones / physiology
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Cell Cycle
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Guided Tissue Regeneration
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Humans
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Molecular Sequence Data
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Osteoblasts / metabolism*
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Osteoblasts / physiology
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Parathyroid Hormone / metabolism*
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Parathyroid Hormone-Related Protein / metabolism*
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Receptor, Parathyroid Hormone, Type 1 / metabolism
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Signal Transduction
Substances
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Parathyroid Hormone
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Parathyroid Hormone-Related Protein
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Receptor, Parathyroid Hormone, Type 1