A novel pedigree with heterozygous germline RUNX1 mutation causing familial MDS-related AML: can these families serve as a multistep model for leukemic transformation?

Leukemia. 2009 Jul;23(7):1364-6. doi: 10.1038/leu.2009.87. Epub 2009 Apr 23.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Core Binding Factor Alpha 2 Subunit / genetics*
  • Female
  • Germ-Line Mutation*
  • Heterozygote*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / complications*
  • Male
  • Models, Biological*
  • Myelodysplastic Syndromes / complications
  • Myelodysplastic Syndromes / genetics*
  • Pedigree

Substances

  • Core Binding Factor Alpha 2 Subunit