Abstract
Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a (129)Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can be monitored by an NMR chemical shift change of cage-HA bound (129)Xe.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biosensing Techniques*
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Cell Line
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Hemagglutinins / chemistry
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Histocompatibility Antigens Class II / chemistry
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Histocompatibility Antigens Class II / metabolism*
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Humans
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Macromolecular Substances / chemistry
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Nuclear Magnetic Resonance, Biomolecular
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Polycyclic Compounds
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Protein Interaction Mapping / methods*
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Triazoles / chemistry
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Xenon Isotopes / chemistry*
Substances
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Hemagglutinins
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Histocompatibility Antigens Class II
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Macromolecular Substances
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Polycyclic Compounds
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Triazoles
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Xenon Isotopes
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cryptophane