Abstract
A new compound, named quinquefoloside-L(c) (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3beta,12beta, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-beta-D-glucopyranosyl (1-->2)beta-D-glucopyranosyl-20-O-beta-D-xylopyanosyl (1-->6) beta-D-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Breast Neoplasms / drug therapy*
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Cell Line, Tumor
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Female
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Ginsenosides / chemistry
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Ginsenosides / isolation & purification
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Ginsenosides / pharmacology
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Ginsenosides / therapeutic use*
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Humans
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Molecular Structure
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Panax / chemistry*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Leaves
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Saponins / isolation & purification
Substances
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Antineoplastic Agents, Phytogenic
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Ginsenosides
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Plant Extracts
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Saponins
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quinquefoloside-L(c)