Ultrastructural evidence of ependymal differentiation in a genetically proven atypical teratoid/rhabdoid tumor

Childs Nerv Syst. 2009 Dec;25(12):1627-31. doi: 10.1007/s00381-009-0926-3. Epub 2009 Jun 25.

Abstract

Introduction: We describe a case of genetically proven atypical teratoid/rhabdoid tumor (ATRT), showing ultrastructural evidence of ependymal differentiation. Such differentiation has not been reported so far in ATRT.

Conclusion: This finding supports the concept that ATRTs as the majority of central nervous system embryonal tumors may derive from an immature and pluripotent neuroectodermal cell capable of differentiating along multiple lineages.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Ventricle Neoplasms / genetics
  • Cerebral Ventricle Neoplasms / surgery
  • Cerebral Ventricle Neoplasms / ultrastructure*
  • Child
  • Cytogenetics
  • Ependyma / surgery
  • Ependyma / ultrastructure*
  • Humans
  • Male
  • Microscopy, Electron
  • Mutation
  • Rhabdoid Tumor / genetics
  • Rhabdoid Tumor / surgery
  • Rhabdoid Tumor / ultrastructure*
  • Teratoma / genetics
  • Teratoma / surgery
  • Teratoma / ultrastructure*