Abstract
MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Biomarkers, Tumor / blood
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Breast / metabolism
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Carcinoembryonic Antigen / blood
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Carcinoma / diagnosis
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Carcinoma / etiology
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Carcinoma / genetics*
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Carcinoma / metabolism
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Cell Transformation, Neoplastic / genetics
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Colon / metabolism
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Computer Systems
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Down-Regulation
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Female
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Gastric Mucosa / metabolism*
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Gene Expression Regulation, Neoplastic*
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Humans
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Lung / metabolism
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Male
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MicroRNAs / biosynthesis*
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MicroRNAs / genetics
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MicroRNAs / physiology
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Middle Aged
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Organ Specificity
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Predictive Value of Tests
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RNA, Neoplasm / biosynthesis*
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RNA, Neoplasm / genetics
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RNA, Neoplasm / physiology
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Reverse Transcriptase Polymerase Chain Reaction
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Stomach Neoplasms / diagnosis
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Stomach Neoplasms / etiology
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Stomach Neoplasms / genetics*
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Stomach Neoplasms / metabolism
Substances
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Biomarkers, Tumor
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Carcinoembryonic Antigen
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MIRN31 microRNA, human
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MicroRNAs
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RNA, Neoplasm