Abstract
1. PAF and LTs may be mediators of the acute gastrointestinal mucosal damage due to endotoxic shock. 2. LTs may be mediators of the acute gastrointestinal mucosal damage due to PAF administration. 3. LMW heparin and unfractionated heparin prevented the increase of LTs due to endotoxin and PAF administration.
MeSH terms
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Acute Disease
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Animals
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Benzoquinones / therapeutic use
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Dogs
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Gastric Mucosa / drug effects*
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Gastric Mucosa / pathology
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Hemorrhage / chemically induced
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Heparin / therapeutic use
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Heparin, Low-Molecular-Weight / therapeutic use*
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Intestinal Mucosa / drug effects*
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Intestinal Mucosa / pathology
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Leukotriene B4 / physiology
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Lipoxygenase Inhibitors
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Necrosis
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Phospholipid Ethers / therapeutic use
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Platelet Activating Factor / antagonists & inhibitors
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Platelet Activating Factor / physiology
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Shock, Septic / complications*
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Shock, Septic / pathology
Substances
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Benzoquinones
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Heparin, Low-Molecular-Weight
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Lipoxygenase Inhibitors
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Phospholipid Ethers
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Platelet Activating Factor
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Leukotriene B4
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2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
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CV 3988
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Heparin