Abstract
In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7+/-0.01 micromol/L.
MeSH terms
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Acetylcholinesterase / chemistry*
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Acetylcholinesterase / metabolism
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Alzheimer Disease / drug therapy
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology
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Drug Design
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Humans
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Indenes / chemical synthesis*
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Indenes / chemistry
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Indenes / pharmacology
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology
Substances
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5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone
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Cholinesterase Inhibitors
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Indenes
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Neuroprotective Agents
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Acetylcholinesterase