Abstract
Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology
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Dendritic Cells / immunology*
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Endotoxins / immunology
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Graft Survival / immunology
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Humans
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Immune Tolerance / immunology
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Interleukin-10 / immunology
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Interleukin-12 / immunology
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Liver / immunology*
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Liver Transplantation / immunology*
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Mice
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Toll-Like Receptor 10 / immunology
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Toll-Like Receptors / immunology
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Transplantation, Homologous / immunology
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Treatment Outcome
Substances
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Endotoxins
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TLR10 protein, human
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Tlr13 protein, mouse
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Toll-Like Receptor 10
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Toll-Like Receptors
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Interleukin-10
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Interleukin-12