Abstract
Two new cerebrosides, 1-O-(beta-d-glucopyranosyloxy)-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(beta-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2'R)-2'-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the pollen of Typha angustifolia. Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside in Typha (Typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS).
Copyright (c) 2009 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arteriosclerosis / prevention & control
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Cardiovascular Agents / chemistry
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Cardiovascular Agents / isolation & purification
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Cardiovascular Agents / pharmacology*
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Cattle
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Cell Proliferation / drug effects
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Cerebrosides / chemistry
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Cerebrosides / isolation & purification
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Cerebrosides / pharmacology
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Endothelial Cells / drug effects
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Endothelium, Vascular / drug effects*
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Glucosylceramides / chemistry
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Glucosylceramides / isolation & purification*
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Glucosylceramides / pharmacology
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Pollen / chemistry
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Typhaceae / chemistry*
Substances
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1-O-(glucopyranosyloxy)-2-(2'-hydroxynonadecanoylamino)-4,13-nonadecene-3-diol
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1-O-(glucopyranosyloxy)-2-(2'-hydroxytricosanoylamino)-8-nonadecene-3,4-diol
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Cardiovascular Agents
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Cerebrosides
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Glucosylceramides
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Plant Extracts