Cladophialophora bantiana and Candida albicans mixed infection in cerebral abscess of an HIV-negative patient

J Infect Dev Ctries. 2008 Jun 1;2(3):245-8. doi: 10.3855/jidc.271.

Abstract

Cladophialophora bantiana is a black fungus recorded rarely as a cause of brain abscess. We describe the first case seen in Vietnam. A 35-year-old, previously healthy male, HIV negative, came to the hospital with a clinical diagnosis of brain tumor. He underwent surgery to remove the well-delineated circumscribed lesion. Pathology, directed physical examination and mycological examination revealed an abscess due to Cladophialophora bantiana, and Candida albicans. After two weeks of treatment with Fluconazole 400 mg per day intravenously, the clinical response remained unsatisfactory. Therapy was then withheld per the family's request.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / administration & dosage
  • Brain / drug effects
  • Brain / microbiology
  • Brain / pathology
  • Brain Abscess / diagnosis
  • Brain Abscess / microbiology*
  • Brain Abscess / physiopathology
  • Brain Abscess / therapy
  • Brain Neoplasms / diagnosis
  • Candida albicans / drug effects
  • Candida albicans / isolation & purification*
  • Diagnosis, Differential
  • Fluconazole / administration & dosage
  • Headache
  • Hemiplegia
  • Humans
  • Infusions, Intravenous
  • Male
  • Mycoses / diagnosis
  • Mycoses / microbiology*
  • Mycoses / physiopathology
  • Mycoses / therapy
  • Saccharomycetales / drug effects
  • Saccharomycetales / isolation & purification*
  • Seizures
  • Treatment Failure
  • Vietnam

Substances

  • Antifungal Agents
  • Fluconazole