An estimated 1 in 1,000 pregnancies is complicated by cancer, and the incidence of cancer during pregnancy is expected to increase as women delay childbirth until their later years. A diagnosis of cancer and the cancer treatment process can be particularly difficult for the pregnant patient, and are challenging for the physician and nurse. This article provides an overview of cancer treatment during pregnancy, discusses current practice guidelines and the oncology nursing role in caring for this unique patient population, and highlights resources for clinicians and patients.