Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3

Sakae Tanaka; Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Keiichi I Nakayama; Kozo Nakamura

doi:10.1007/978-1-4419-1050-9_12

Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3

Adv Exp Med Biol. 2010:658:111-6. doi: 10.1007/978-1-4419-1050-9_12.

Authors

Sakae Tanaka¹, Hidetoshi Wakeyama, Toru Akiyama, Katsuhiko Takahashi, Hitoshi Amano, Keiichi I Nakayama, Kozo Nakamura

Affiliation

¹ Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. [email protected]

PMID: 19950021
DOI: 10.1007/978-1-4419-1050-9_12

Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis Regulatory Proteins / metabolism*
Apoptosis*
Bcl-2-Like Protein 11
Caspase 3 / deficiency
Caspase 3 / metabolism*
Cell Survival
Down-Regulation
Embryo, Mammalian / cytology
Fibroblasts / metabolism
Membrane Proteins / metabolism*
Mice
Models, Biological
Osteoclasts / cytology*
Osteoclasts / enzymology*
Proto-Oncogene Proteins / metabolism*

Substances

Apoptosis Regulatory Proteins
Bcl-2-Like Protein 11
Bcl2l11 protein, mouse
Membrane Proteins
Proto-Oncogene Proteins
Caspase 3