Sensitivity and specificity of BCG scar reading among HIV-infected children

Vaccine. 2010 Feb 25;28(9):2067-9. doi: 10.1016/j.vaccine.2009.12.034. Epub 2010 Jan 6.

Abstract

BCG scar has been used as an indicator of vaccination with BCG in the past, but the validity of scar among HIV-positive children is still unknown. The validity of BCG scar reading among such children was estimated, using three different gold standards. The sensitivity ranged from 81.3% (95%-CI: 78.0-84.2) to 91.6% (95%-CI: 88.4-94.0), when the gold standards were, respectively, information from the adult responsible for the child and the vaccination card. The specificity ranged from 90.5% (95% CI: 81.6-95.5) to 94.1% (95% CI: 87.7-97.4), when the gold standards were, respectively, the vaccination card and information from the adult responsible for the child. Reading of BCG scar was shown to be a good indicator for vaccination in the past, among HIV-infected children.

Publication types

  • Validation Study

MeSH terms

  • Angola
  • BCG Vaccine / administration & dosage*
  • Case-Control Studies
  • Child, Preschool
  • Cicatrix*
  • Female
  • HIV Seropositivity / immunology*
  • Humans
  • Infant
  • Male
  • Medical Records
  • Sensitivity and Specificity
  • Tuberculosis / epidemiology
  • Tuberculosis / prevention & control

Substances

  • BCG Vaccine