Abstract
The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Benzaldehydes / chemical synthesis*
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Benzaldehydes / metabolism
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Benzaldehydes / pharmacology
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Molecular Structure
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Organophosphates / chemical synthesis*
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Organophosphates / metabolism
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Organophosphates / pharmacology
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Pyridoxal Phosphate / analogs & derivatives*
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Pyridoxal Phosphate / chemistry*
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Spectrum Analysis
Substances
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1-deazapyridoxal 5'-phosphate
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Benzaldehydes
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Organophosphates
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Pyridoxal Phosphate