Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2

Food Chem Toxicol. 2010 Jan:48 Suppl 1:S49-56. doi: 10.1016/j.fct.2009.10.015.

Abstract

The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzene / toxicity*
  • Benzene Derivatives / toxicity*
  • Carcinogens / toxicity*
  • Data Interpretation, Statistical
  • Diet
  • Dose-Response Relationship, Drug
  • Female
  • Food Contamination / analysis*
  • Humans
  • Male
  • Mice
  • Models, Statistical
  • Mutagens / toxicity*
  • Neoplasms / chemically induced
  • Neoplasms / epidemiology
  • Rats

Substances

  • Benzene Derivatives
  • Carcinogens
  • Mutagens
  • Benzene