Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: ethyl carbamate (CAS 51-79-6)

Food Chem Toxicol. 2010 Jan:48 Suppl 1:S63-8. doi: 10.1016/j.fct.2009.10.032.

Abstract

Ethyl carbamate is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for alveolar and bronchiolar adenoma or carcinoma in male and female mice combined gave a BMDL(10) of 0.25 mg/kg-bw/day. The dietary exposure from consumption of foods and non-alcoholic beverage was estimated to be 1 microg/person/day (15 ng/kg-bw/day), while the exposure of a high-percentile consumer of alcoholic beverages was estimated to be 5 microg/person per day (80 ng/kg-bw/day). The corresponding calculated MOEs were 16600 and 3125, respectively.

Publication types

  • Review

MeSH terms

  • Anesthetics, Intravenous / toxicity*
  • Animals
  • Carcinogens / toxicity*
  • Data Interpretation, Statistical
  • Diet
  • Dose-Response Relationship, Drug
  • Female
  • Food Contamination / analysis*
  • Humans
  • Male
  • Mice
  • Models, Statistical
  • Mutagens / toxicity*
  • Rats
  • Urethane / toxicity*

Substances

  • Anesthetics, Intravenous
  • Carcinogens
  • Mutagens
  • Urethane