Failure of molecular diagnostics in chronic myeloid leukemia: an aberrant form of e13a2 BCR-ABL transcript causing false-negative results by standard polymerase chain reaction

Leuk Lymphoma. 2010 Mar;51(3):558-61. doi: 10.3109/10428190903572219.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Exons
  • False Negative Reactions
  • Fusion Proteins, bcr-abl / metabolism*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Male
  • Models, Genetic
  • Pathology, Molecular / methods
  • Polymerase Chain Reaction / methods*
  • Proto-Oncogene Proteins c-bcr / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic

Substances

  • Fusion Proteins, bcr-abl
  • Proto-Oncogene Proteins c-bcr