Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model

Resuscitation. 2010 May;81(5):603-8. doi: 10.1016/j.resuscitation.2010.01.014. Epub 2010 Feb 16.

Abstract

Aim of the study: This study aimed at evaluating (I) the impact of different intra-arrest hypothermia levels on the expression of selected cytokines and (II) their prognostic value for 9-day survival.

Methods: Female Large White pigs (n=21, 31-38 kg) were subjected to 15 min of ventricular fibrillation, followed by intra-arrest cardiopulmonary bypass cooling for 1, 3, or 5 min achieving brain temperatures (Tbr) of 30.4+/-1.6, 24.2+/-4.6 and 18.8+/-4.0 degrees C. After 40 min of controlled rewarming, pigs were defibrillated and kept at Tbr of 34.5 degrees C for 20 h, survival was for 9 days. Plasma samples were analysed for interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha), and IL-10 levels by ELISA. Total RNA out of peripheral blood mononuclear cells was analysed by real-time PCR for IL-1, IL-2, IL-4, IL-10, TNF-alpha, interferon-gamma, inducible NO synthase, and heme oxygenase-1 gene expressions.

Results: Plasma IL-6 and TNF-alpha levels significantly (p=0.0001 and 0.0003) increased in all animals within 1h after resuscitation with no significant differences between groups. Pigs surviving exhibited a decrease in IL-10 expression between baseline and intra-arrest values as compared to non-surviving animals, which showed a slight increase (p=0.0078). ROC curve analysis revealed that changes in IL-10 expression had a good prognostic power for survival to day 9 (area under the curve=0.882).

Conclusion: The systemic inflammatory response syndrome after cardiac arrest was reflected by a remarkable increase of plasma IL-6 and TNF-alpha levels. Intra-arrest hypothermia levels did not influence the expression of selected cytokines. As prognostic marker for survival IL-10 was identified with decreasing mRNA levels during cardiac arrest in survivors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers
  • Cardiopulmonary Bypass
  • Disease Models, Animal
  • Down-Regulation
  • Electric Countershock
  • Female
  • Heart Arrest / complications
  • Heart Arrest / diagnosis*
  • Heart Arrest / mortality
  • Heart Arrest / physiopathology*
  • Heart Arrest / therapy
  • Hypothermia, Induced
  • Interleukin-10 / blood
  • Interleukin-10 / genetics*
  • Interleukin-6 / blood
  • Leukocytes, Mononuclear / metabolism
  • RNA, Messenger
  • Resuscitation
  • Survival Rate
  • Sus scrofa
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / genetics
  • Ventricular Fibrillation / etiology

Substances

  • Biomarkers
  • Interleukin-6
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Interleukin-10