Mumps vaccine effectiveness in highly immunized populations

Vaccine. 2010 Apr 30;28(20):3567-70. doi: 10.1016/j.vaccine.2010.02.107. Epub 2010 Mar 10.

Abstract

The aim of the study was to investigate effectiveness of mumps MMR component in communities with high MMR coverage. Outbreak-related cases of mumps born between 1995 and 2005 notified to Navarre and Catalonia public health services during the period 2005-2007 were studied. Vaccine effectiveness (VE) and their 95%CI were calculated using the screening method. Of 47 confirmed, 85.1% immunized with at least one dose (1MMR) and 44.9% with two (2MMR). Estimated VE was 85.4% (95%CI: 67.3-93.4) for 1MMR and 88.5% (95%CI: 78.1-93.9) for 2MMR. High 2MMR coverage, improved confirmation techniques and further VE studies with all confirmed cases are needed to prevent further outbreaks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Disease Outbreaks*
  • Humans
  • Infant
  • Mumps / epidemiology
  • Mumps / prevention & control*
  • Mumps Vaccine / administration & dosage
  • Mumps Vaccine / immunology*
  • Spain / epidemiology
  • Young Adult

Substances

  • Mumps Vaccine