Optical small animal imaging in the drug discovery process

S Dufort; L Sancey; C Wenk; V Josserand; J L Coll

doi:10.1016/j.bbamem.2010.03.016

Optical small animal imaging in the drug discovery process

Biochim Biophys Acta. 2010 Dec;1798(12):2266-73. doi: 10.1016/j.bbamem.2010.03.016. Epub 2010 Mar 24.

Authors

S Dufort¹, L Sancey, C Wenk, V Josserand, J L Coll

Affiliation

¹ Institut Albert Bonniot, BP 170, 38 042 Grenoble cedex 9, France.

PMID: 20346346
DOI: 10.1016/j.bbamem.2010.03.016

Abstract

Molecular imaging of tumors in preclinical models is of the utmost importance for developing innovative cancer treatments. This field is moving extremely rapidly, with recent advances in optical imaging technologies and sophisticated molecular probes for in vivo imaging. The aim of this review is to provide a succinct overview of the imaging modalities available for rodents and with focus on describing optical probes for cancer imaging.

Publication types

Review

MeSH terms

Animals
Drug Delivery Systems / methods*
Microscopy / methods
Molecular Probes* / chemistry
Molecular Probes* / pharmacology
Neoplasms, Experimental / drug therapy
Neoplasms, Experimental / metabolism*
Neoplasms, Experimental / pathology*
Rodentia

Substances

Molecular Probes