Abstract
Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Apoptosis / drug effects
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Baccharis / chemistry*
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Caco-2 Cells
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Caspase 3 / metabolism
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Cell Proliferation / drug effects*
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / metabolism
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DNA Replication / drug effects
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Dose-Response Relationship, Drug
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Humans
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Porifera / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Sesquiterpenes
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curcuphenol
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Caspase 3