Prevalence and morphological types of anaemia and hookworm infestation in the medical emergency ward, Mulago Hospital, Uganda

S Afr Med J. 2009 Dec 7;99(12):881-6.

Abstract

Introduction: Anaemia is common worldwide, although the burden is highest in developing countries where nutrient deficiencies and chronic infections are prevalent.

Objective: To determine the prevalence and morphological types of anaemia and assess the hookworm burden among patients in the medical emergency ward at Mulago national referral hospital, Uganda.

Methods: In a cross-sectional descriptive study 395 patients were recruited by systematic random sampling and their socio-demographic characteristics and clinical details collected. A complete blood count and peripheral film examination were done and stool examined for hookworm ova.

Statistical analysis: Data were processed using Epi-Info version 6 and Stata version 9. The chi-square test was used for categorical variables and Student's t-test for non-categorical variables. Multiple logistic regression was used to determine factors predictive of anaemia.

Results: Of the patients 255 (64.6%) had anaemia. The prevalence was higher among males (65.8%) than females (63.7%). Fatigue (odds ratio (OR) 2.1, confidence interval (CI) 1.37 - 3.24), dizziness (OR 1.64, CI 1.07 - 2.44), previous blood transfusion (OR 2.83, CI 1.32 - 6.06), lymphadenopathy (OR 2.99, CI 1.34 - 6.66) and splenomegaly (OR 5.22, CI 1.78 - 15.28) were significantly associated with anaemia. Splenomegaly, low body mass index (BMI) (<19) and being HIV positive were independently associated with anaemia. The commonest type of anaemia was hypochromic microcytic (34.1%). Only 10.6% of anaemic patients had hookworm infestation.

Conclusions: In our study the prevalence of anaemia (64.6%) was very high. Splenomegaly, HIV infection and low BMI were independently associated with anaemia. The commonest type of anaemia was microcytic hypochromic (34.1%). There was a low prevalence of hookworm infestation.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Ancylostomatoidea / isolation & purification*
  • Anemia / diagnosis
  • Anemia / epidemiology*
  • Anemia / etiology
  • Animals
  • Cross-Sectional Studies
  • Diagnosis, Differential
  • Feces / parasitology
  • Female
  • Follow-Up Studies
  • Hemoglobins / metabolism
  • Hookworm Infections / complications*
  • Hookworm Infections / epidemiology
  • Hookworm Infections / transmission
  • Humans
  • Infectious Disease Transmission, Patient-to-Professional*
  • Male
  • Medical Staff, Hospital*
  • Middle Aged
  • Prevalence
  • Retrospective Studies
  • Uganda / epidemiology
  • Young Adult

Substances

  • Hemoglobins