[Clinical course of premature and newborn infants of mothers with HELLP syndrome]

Z Geburtshilfe Perinatol. 1991 Jan-Feb;195(1):16-20.
[Article in German]

Abstract

The HELLP-syndrome is complicated by a maternal mortality of 3.5% and a perinatal mortality between 9.5 and 60%. It is a variant of severe preeclampsia which includes hemolysis, elevated liver enzymes and low platelets. It is described in the literature that neonates of mothers with HELLP-syndrome show characteristic symptoms especially thrombocytopenia, leukocytopenia and prenatal somatic dystrophy. In this retrospective investigation of 36 preterm and term infants of mothers with HELLP-syndrome we found the following results: 1. Thrombocytopenia was seen in 11% and leucocytopenia in 12% of the analysed cases. Anemia was seen in 10% of the analysed neonates. They needed transfusion of blood. The rate of prenatal somatic dystrophy was increased (58%). 2. Elevated blood pressure was observed in 29% of the neonates within the analysed interval. The time of artificial ventilation of preterm infants with maternal HELLP-syndrome was in 37% extended in comparison with infants without HELLP-syndrome in pregnancy. 3. The perinatal mortality was 8%. All observed infants during delivery and of the neonatal period in our collective survived.

Publication types

  • English Abstract

MeSH terms

  • Alanine Transaminase / blood
  • Anemia, Hemolytic / diagnosis*
  • Anemia, Hemolytic / enzymology
  • Anemia, Hemolytic / mortality
  • Aspartate Aminotransferases / blood
  • Birth Weight / physiology
  • Female
  • Fetal Growth Retardation / diagnosis
  • Fetal Growth Retardation / enzymology
  • Fetal Growth Retardation / mortality
  • Gestational Age
  • Humans
  • Infant, Newborn
  • L-Lactate Dehydrogenase / blood
  • Leukopenia / diagnosis
  • Leukopenia / enzymology
  • Leukopenia / mortality
  • Liver Function Tests*
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / enzymology
  • Pre-Eclampsia / mortality
  • Pregnancy
  • Syndrome
  • Thrombocytopenia / diagnosis*
  • Thrombocytopenia / enzymology
  • Thrombocytopenia / mortality

Substances

  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase