Synthesis and Characterization of Shape Memory (Meth)Acrylate Co-Polymers and their Cytocompatibility In Vitro

J Biomater Sci Polym Ed. 2011;22(1-3):1-17. doi: 10.1163/092050609X12567412849136.

Abstract

A series of novel transparent shape memory co-polymers, made from (meth)acrylate monomers, intended to be used as intraocular lens, was synthesized. The thermo-mechanical properties, shape memory properties and optical properties of the co-polymers could be adjusted by using monomers with various alkyl chain lengths. The cytocompatibility of the prepared co-polymers to L929 mouse connective tissue fibroblasts was demonstrated in vitro, and the co-polymers exhibited favorable cytocompatibility, supporting cell viability and proliferation. This study showed that the prepared co-polymers, which exhibited good flexibility, adjustable shape memory properties, high transparency and favorable cytocompatibility, could find great promising applications as intraocular lens.

Keywords: CYTOCOMPATIBILITY; INTRAOCULAR LENS; MECHANICAL PROPERTY; SHAPE MEMORY; TRANSPARENCY.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials* / chemical synthesis
  • Biocompatible Materials* / chemistry
  • Calorimetry, Differential Scanning
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Cell Line
  • Cell Proliferation / physiology
  • Cell Survival / physiology
  • Fibroblasts / physiology
  • Materials Testing
  • Methacrylates* / chemistry
  • Mice
  • Orbital Implants
  • Pliability
  • Polymers* / chemical synthesis
  • Polymers* / chemistry
  • Prosthesis Design
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Biocompatible Materials
  • Methacrylates
  • Polymers