Abstract
In this study, we assessed the oxidative stress parameters in rats submitted to an animal model of mania induced by ouabain (OUA), which included the use of lithium (Li) and valproate (VPA). Li and VPA treatment reversed and prevented the OUA-induced damage in these structures, however, this effect varies depending on the brain region and treatment regimen. Moreover, the activity of the antioxidant enzymes, namely, superoxide dismutase (SOD) and catalase (CAT) was found to be increased and decreased, respectively, in the brain of OUA-administered rats. Li and VPA modulated SOD and CAT activities in OUA-subjected rats in both experimental models. Our results support the notion that Li and VPA exert antioxidant-like properties in the brain of rats submitted to animal model of mania induced by ouabain.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Antimanic Agents / pharmacology
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Antimanic Agents / therapeutic use*
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Bipolar Disorder / chemically induced*
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / metabolism
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Bipolar Disorder / pathology
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Brain / drug effects
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Brain / enzymology
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Brain / pathology
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Catalase / metabolism
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Disease Models, Animal
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Drug Interactions
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Gene Expression Regulation, Enzymologic / drug effects
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Injections, Intraventricular
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Lithium Chloride / pharmacology
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Lithium Chloride / therapeutic use*
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Male
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Ouabain / adverse effects*
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Protein Carbonylation / drug effects
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Rats
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Rats, Wistar
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Superoxide Dismutase / metabolism
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Thiobarbituric Acid Reactive Substances / metabolism
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Valproic Acid / pharmacology
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Valproic Acid / therapeutic use*
Substances
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Antimanic Agents
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Thiobarbituric Acid Reactive Substances
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Ouabain
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Valproic Acid
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Catalase
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Superoxide Dismutase
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Lithium Chloride