Cardiac resynchronization therapy (CRT) is a widely accepted therapeutic modality in a selected group of patients with heart failure. The broad implementation of CRT into clinical practice is hampered by the complexity of the implantation procedure, especially the implantation of left ventricular (LV) lead. We here report a case in which the use of the pacing lead guidewire resulted in a substantial reduction in the pacing threshold of LV lead, and the threshold of LV lead was stable in 12-month follow-up.