Identification of prolyliminopeptidase-negative Neisseria gonorrhoeae strains in Canada

Sex Transm Dis. 2011 Jan;38(1):40-2. doi: 10.1097/OLQ.0b013e3181ebd524.

Abstract

Neisseria gonorrhoeae strains that fail to produce the enzyme prolyliminopeptidase have been identified in Canada. Commercial test panels use prolyliminopeptidase activity for identification and to avoid the misdiagnosis of gonorrhea, at least 2 distinct methods for the confirmatory identification of N. gonorrhoeae is imperative.

MeSH terms

  • Adult
  • Aminopeptidases / metabolism*
  • Anti-Bacterial Agents / pharmacology
  • Canada / epidemiology
  • Female
  • Gonorrhea / diagnosis*
  • Gonorrhea / epidemiology*
  • Gonorrhea / microbiology
  • Humans
  • Male
  • Microbial Sensitivity Tests / methods
  • Middle Aged
  • Neisseria gonorrhoeae / classification*
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / enzymology*
  • Population Surveillance / methods*
  • Serotyping
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Aminopeptidases
  • prolyl aminopeptidase