Abstract
Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes' anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic-like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acceleration / adverse effects*
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Amitriptyline / pharmacology
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Amitriptyline / therapeutic use
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Animals
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Antidepressive Agents / pharmacology
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Antidepressive Agents / therapeutic use*
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Anxiety / drug therapy
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Anxiety / etiology
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Behavior, Animal / drug effects*
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Brain Injuries / complications
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Brain Injuries / drug therapy*
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Brain Injuries / psychology
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Bupropion / pharmacology
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Bupropion / therapeutic use
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Citalopram / pharmacology
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Citalopram / therapeutic use
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Cyclohexanols / pharmacology
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Cyclohexanols / therapeutic use
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Exploratory Behavior / drug effects
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Fear / drug effects
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Male
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Neuronal Plasticity
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Neurotransmitter Uptake Inhibitors / pharmacology
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Neurotransmitter Uptake Inhibitors / therapeutic use*
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Norepinephrine / physiology*
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Rats
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Rats, Wistar
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Reflex, Startle / drug effects
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Serotonin / physiology*
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Social Behavior
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Venlafaxine Hydrochloride
Substances
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Antidepressive Agents
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Cyclohexanols
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Neurotransmitter Uptake Inhibitors
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Bupropion
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Citalopram
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Amitriptyline
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Serotonin
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Venlafaxine Hydrochloride
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Norepinephrine