Metabolome-proteome differentiation coupled to microbial divergence

mBio. 2010 Oct 26;1(5):e00246-10. doi: 10.1128/mBio.00246-10.

Abstract

Tandem high-throughput proteomics and metabolomics were employed to functionally characterize natural microbial biofilm communities. Distinct molecular signatures exist for each analyzed sample. Deconvolution of the high-resolution molecular data demonstrates that identified proteins and detected metabolites exhibit organism-specific correlation patterns. These patterns are reflective of the functional differentiation of two bacterial species that share the same genus and that co-occur in the sampled microbial communities. Our analyses indicate that the two species have similar niche breadths and are not in strong competition with one another.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacteria / chemistry*
  • Bacteria / growth & development
  • Bacteria / metabolism*
  • Biofilms*
  • Environmental Microbiology*
  • High-Throughput Screening Assays
  • Metabolome*
  • Proteome / analysis*
  • Statistics as Topic

Substances

  • Proteome