Aim: To investigate the effect of hyperthermia on apoptosis of cultivated striatum neurons in the rat.
Methods: After 30 min hyperthermia in 43 degrees, the Ca2+ concentration, the mitochondria membrane potential of the neuron were detected by Laser Scanning Confocal Microscopy (LSCM). The apoptosis of striatum neurons was detected by TUNEL staining.
Results: Heat stress at 43 degrees C for 40 min caused an increase in the Ca2+ concentration of striatum neurons and a decrease in the mitochondria membrane potential of the striatum neurons.
Conclusion: The striatum shows more apoptosis neurons after heat stress.