An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection

Vaccine. 2011 Feb 17;29(9):1783-90. doi: 10.1016/j.vaccine.2010.12.111. Epub 2011 Jan 8.

Abstract

Salmonella enterica serovar Typhimurium has long been recognised as a zoonotic pathogen of economic significance in animals and humans. Attempts to protect humans and livestock may be based on immunization with vaccines aimed to induce a protective response. We recently demonstrated that the oral administration of a Salmonella enterica serovar Typhimurium strain unable to synthesize the zinc transporter ZnuABC is able to protect mice against systemic salmonellosis induced by a virulent homologous challenge. This finding suggested that this mutant strain could represent an interesting candidate vaccine for mucosal delivery. In this study, the protective effect of this Salmonella strain was tested in a streptomycin-pretreated mouse model of salmonellosis that is distinguished by the capability of evoking typhlitis and colitis. The here reported results demonstrate that mice immunized with Salmonella enterica serovar Typhimurium (S. Typhimurium) SA186 survive to the intestinal challenge and, compared to control mice, show a reduced number of virulent bacteria in the gut, with milder signs of inflammation. This study demonstrates that the oral administration a of S. Typhimurium strain lacking ZnuABC is able to elicit an effective immune response which protects mice against intestinal S. Typhimurium infection. These results, collectively, suggest that the streptomycin-pretreated mouse model of S. typhimurium infection can represent a valuable tool to screen S. typhimurium attenuated mutant strains and potentially help to assess their protective efficacy as potential live vaccines.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • ATP-Binding Cassette Transporters / immunology*
  • Animals
  • Disease Models, Animal*
  • Enterocolitis / immunology
  • Enterocolitis / mortality
  • Enterocolitis / prevention & control*
  • Female
  • Genetic Predisposition to Disease
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / microbiology
  • Mice
  • Mice, Inbred DBA
  • Mutation
  • Random Allocation
  • Salmonella Infections, Animal / immunology
  • Salmonella Infections, Animal / mortality
  • Salmonella Infections, Animal / prevention & control*
  • Salmonella Vaccines / administration & dosage*
  • Salmonella Vaccines / immunology
  • Salmonella enterica / immunology*
  • Salmonella enterica / pathogenicity
  • Salmonella typhimurium / immunology*
  • Salmonella typhimurium / pathogenicity
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology
  • Zinc / immunology
  • Zinc / metabolism

Substances

  • ATP-Binding Cassette Transporters
  • Salmonella Vaccines
  • Vaccines, Attenuated
  • Zinc