In vitro effect of Knotolan, a new lignan from Abies sibirica, on the growth of hormone-dependent breast cancer cells

O S Zhukova; L V Fetisova; A V Trishin; N Yu Anisimova; A M Scherbakov; D V Yashunskii; D E Tsvetkov; V M Men'shov; M V Kiselevskii; N E Nifant'ev

doi:10.1007/s10517-010-0981-5

In vitro effect of Knotolan, a new lignan from Abies sibirica, on the growth of hormone-dependent breast cancer cells

Bull Exp Biol Med. 2010 Oct;149(4):511-4. doi: 10.1007/s10517-010-0981-5.

[Article in English, Russian]

Authors

O S Zhukova¹, L V Fetisova, A V Trishin, N Yu Anisimova, A M Scherbakov, D V Yashunskii, D E Tsvetkov, V M Men'shov, M V Kiselevskii, N E Nifant'ev

Affiliation

¹ N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.

PMID: 21234454
DOI: 10.1007/s10517-010-0981-5

Abstract

Here we present antiestrogenic effects of Knotolan, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17β-estradiol on hormone-dependent MCF-7 cells.

MeSH terms

Abies / chemistry
Breast Neoplasms / drug therapy*
Butylene Glycols / therapeutic use*
Cell Line, Tumor
Cell Proliferation / drug effects
Estradiol / pharmacology
Female
Humans
Lignans / therapeutic use*
Neoplasms, Hormone-Dependent / drug therapy*

Substances

Butylene Glycols
Lignans
Estradiol
secoisolariciresinol