Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms

AIDS Res Hum Retroviruses. 2011 Oct;27(10):1135-7. doi: 10.1089/AID.2010.0364. Epub 2011 Feb 14.

Abstract

To investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B (p = 0.001).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Cross-Sectional Studies
  • Female
  • HIV Envelope Protein gp120 / genetics
  • HIV Envelope Protein gp41 / genetics
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • HIV-1 / pathogenicity
  • Humans
  • Male
  • Middle Aged
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / blood
  • RNA, Viral / genetics
  • Risk Factors
  • Singapore / epidemiology
  • Young Adult
  • pol Gene Products, Human Immunodeficiency Virus / genetics

Substances

  • HIV Envelope Protein gp120
  • HIV Envelope Protein gp41
  • RNA, Viral
  • gp120 protein, Human immunodeficiency virus 1
  • gp41 protein, Human immunodeficiency virus 1
  • pol Gene Products, Human Immunodeficiency Virus

Associated data

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