Cleavable β-cyclodextrin nanocapsules incorporating Gd(III)-chelates as bioresponsive MRI probes

Chem Commun (Camb). 2011 Mar 21;47(11):3144-6. doi: 10.1039/c0cc05428c. Epub 2011 Jan 26.

Abstract

Perthiolated β-cyclodextrin-based nanocapsules incorporating diaquo Gd(III)-complexes represent a promising new type of bioresponsive MRI contrast agent, showing a pronounced relaxivity change upon degradation in a reducing environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry*
  • Contrast Media / chemistry*
  • Gadolinium / chemistry*
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging
  • Nanocapsules / chemistry*
  • beta-Cyclodextrins / chemistry*

Substances

  • Chelating Agents
  • Contrast Media
  • Nanocapsules
  • beta-Cyclodextrins
  • Gadolinium
  • betadex