Gap in the prevalence of neutralising antibodies to polioviruses in antenatal women in southern India

Jacob John; Asha M Abraham; Jayaprakash Muliyil; T Jacob John; J M Deshpande; Gagandeep Kang

doi:10.1016/j.trstmh.2010.12.005

Gap in the prevalence of neutralising antibodies to polioviruses in antenatal women in southern India

Trans R Soc Trop Med Hyg. 2011 Mar;105(3):179-80. doi: 10.1016/j.trstmh.2010.12.005. Epub 2011 Jan 31.

Authors

Jacob John¹, Asha M Abraham, Jayaprakash Muliyil, T Jacob John, J M Deshpande, Gagandeep Kang

Affiliation

¹ Department of Community Health, Christian Medical College, Vellore 632002, Tamil Nadu, India. [email protected]

PMID: 21277608
DOI: 10.1016/j.trstmh.2010.12.005

Abstract

With the disappearance of circulating wild poliovirus and improved sanitation, protective antibody levels may wane over time following oral poliovirus vaccine (OPV) administration. This study evaluated the seroprevalence of neutralising antibodies to vaccine polioviruses among young Indian women who had received at least three doses of OPV as primary immunisation. Of 60 women studied, 27 (45%) had antibody titres of <1:8 to one or more polioviruses, with the lowest levels for poliovirus types 3 and 1. These findings represent a possible immunity gap and this needs to be confirmed with further studies, which could include a challenge with vaccine virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / blood*
Antibodies, Viral / blood*
Female
Humans
India / epidemiology
Poliovirus / immunology*
Poliovirus Vaccine, Oral / blood
Poliovirus Vaccine, Oral / immunology*
Pregnancy
Prevalence
Seroepidemiologic Studies
Young Adult

Substances

Antibodies, Neutralizing
Antibodies, Viral
Poliovirus Vaccine, Oral