Antithymocyte globulin-induced acute lung injury during transplantation for aplastic anemia

J Pediatr Hematol Oncol. 2011 Mar;33(2):150-2. doi: 10.1097/MPH.0b013e3182003095.

Abstract

A 10-year-old boy with acquired, very severe aplastic anemia developed acute lung injury after the administration of equine antithymocyte globulin, during conditioning for allogenic bone marrow transplantation. Limited cases of antithymocyte globulin-induced acute lung injury have been described in adults. The respiratory worsening was sudden and required mechanical ventilation. The clinical course was complicated by sepsis with Escherichia coli, vancomycin-resistant enterococci, and Stenotrophomonas maltophilia. Implications for treatment are discussed and earlier literature is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Acute Lung Injury / chemically induced*
  • Acute Lung Injury / physiopathology
  • Anemia, Aplastic / surgery*
  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Antilymphocyte Serum / adverse effects*
  • Bacterial Infections / complications
  • Bone Marrow Transplantation*
  • Child
  • Cyclophosphamide / therapeutic use
  • Horses
  • Humans
  • Male
  • Penicillanic Acid / analogs & derivatives
  • Penicillanic Acid / therapeutic use
  • Piperacillin / therapeutic use
  • Piperacillin, Tazobactam Drug Combination
  • Sepsis / complications
  • Transplantation Conditioning / adverse effects*
  • Vancomycin / therapeutic use
  • Vidarabine / analogs & derivatives
  • Vidarabine / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Antilymphocyte Serum
  • Piperacillin, Tazobactam Drug Combination
  • Vancomycin
  • Penicillanic Acid
  • Cyclophosphamide
  • Vidarabine
  • fludarabine
  • Piperacillin