Abstract
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Brasilien
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Casearia / chemistry*
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Diterpenes, Clerodane / chemistry
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Diterpenes, Clerodane / isolation & purification*
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Diterpenes, Clerodane / pharmacology*
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Doxorubicin / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Plant Leaves / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Clerodane
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Doxorubicin