1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia

J Psychiatr Res. 2011 Sep;45(9):1135-9. doi: 10.1016/j.jpsychires.2011.02.004. Epub 2011 Mar 11.

Abstract

Using proton magnetic resonance spectroscopy biochemical characteristics in early stages of schizophrenia were examined. N-acetylaspartate, choline and creatine were measured in hippocampus, anterior cingulate gyrus (ACC) and medial prefrontal cortex (mPFC) of 24 first episode and 30 ultra-high risk patients. Careful LCModel analyses revealed no differences between the patient groups and 31 healthy controls, casting doubt upon the idea of metabolic changes in early stages of psychosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / metabolism*
  • Brain / pathology
  • Brain Mapping
  • Chi-Square Distribution
  • Choline / metabolism
  • Creatine / metabolism
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Protons
  • Schizophrenia / diagnosis*
  • Schizophrenia / metabolism*
  • Young Adult

Substances

  • Protons
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline