Getting closer to the dirty little secret

Karin Pelka; Eicke Latz

doi:10.1016/j.immuni.2011.04.003

Getting closer to the dirty little secret

Immunity. 2011 Apr 22;34(4):455-8. doi: 10.1016/j.immuni.2011.04.003.

Authors

Karin Pelka¹, Eicke Latz

Affiliation

¹ Institute of Innate Immunity, Biomedical Center, 1G008, University Hospitals, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Abstract

The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.

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