The many faces of tau

Neuron. 2011 May 12;70(3):410-26. doi: 10.1016/j.neuron.2011.04.009.

Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Microtubules / metabolism
  • Models, Biological
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Signal Transduction / physiology
  • tau Proteins / physiology*

Substances

  • tau Proteins