Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia

Org Lett. 2011 Jun 17;13(12):3036-9. doi: 10.1021/ol200878w. Epub 2011 May 18.

Abstract

Volvalerelactones A and B (1 and 2), two new sesquiterpenoid lactones with an unprecedented 3/7/6 tricyclic ring system, were isolated from the roots of Valeriana officinalis var. latifolia. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography, and the absolute configuration was assigned by computational methods. The possible biosynthetic pathways of 1 and 2 were also proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification*
  • Cholinesterase Inhibitors / pharmacology
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Lactones / chemistry*
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Molecular Conformation
  • Molecular Structure
  • Nerve Growth Factor / drug effects
  • Nerve Growth Factor / metabolism
  • Neurites / drug effects
  • Nuclear Magnetic Resonance, Biomolecular
  • PC12 Cells
  • Plant Roots / chemistry
  • Rats
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Valerian / chemistry*

Substances

  • Cholinesterase Inhibitors
  • Lactones
  • Sesquiterpenes
  • volvalerelactone A
  • volvalerelactone B
  • Nerve Growth Factor